Before trying any new supplements for depression, it’s important to ask a trusted healthcare professional about potential medication interactions or safety concerns.

While supplements may be helpful in managing depression, they are not a cure for the condition. Therefore, when selecting supplements, be wary of products that claim to treat or cure depression.

A quick look at the best supplements for depression

  • Best with rhodiola: Pure Encapsulations Rhodiola Rosea
  • Best with saffron: NOW Saffron 50 mg
  • Best with omega-3s: Nordic Naturals EPA Xtra
  • Best with N-acetyl-L-cysteine: Pure Encapsulations NAC 900 mg
  • Best with vitamin D: Thorne Vitamin D/K2 Liquid
  • Best with B vitamins: Klaire Labs B-Complex Plus
  • Best with zinc: Pure Encapsulations Zinc
  • Best with SAM-e: Jarrow Formulas SAMe 400 mg
  • Best with magnesium: Bluebonnet Magnesium Glycinate
  • Best with creatine: Thorne Creatine

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